The mTOR signaling pathway acts as a molecular systems integrator to support organismal and cellular interactions with the environment. The mTOR pathway regulates homeostasis by directly influencing …

Oct 2, 2023 · Here, we provide the detailed structure of mTOR, its complexes, and the comprehensive role of upstream regulators, as well as downstream effectors of mTOR signaling cascades in the …

Aug 5, 2025 · Discover how mTOR, a fundamental cellular signaling pathway, governs cell growth, metabolism, and survival, profoundly influencing health.

Regulation of Autophagy: mTOR plays a central role in regulating autophagy through two major signaling pathways, i.e., the AMPK-mTOR pathway and the PI3K-Akt-mTOR pathway.

Dec 23, 2025 · Discover the mTOR pathway and its role in cellular growth and metabolism. Click here to explore the intricacies of this vital signaling pathway.

Oct 1, 2023 · In this review, we summarize recent advances in understanding the structural mechanisms of how the mTOR pathway operates in the cell. For clarity, we refer to proteins found in different …

Jul 23, 2025 · The mTOR signaling pathway, which is frequently activated in tumors, is crucial for tumor metabolism because it not only controls protein synthesis and gene transcription to control immune …

The mTOR signaling pathway is essential for regulating cell growth and mammalian metabolism. The mTOR kinase forms two complexes, mTORC1 and mTORC2, which respond to external stimuli and …

Feb 7, 2025 · We focus on the molecular mechanisms by which mTOR signaling regulates cardiac diseases and the potential of mTOR inhibitors and related regulatory drugs in preventing these …

Jul 21, 2025 · Explore the mTOR pathway, a core mechanism that directs cellular resources toward either growth or cleanup, influencing both aging and metabolic health.