Biological polymers' conformations have been measured using atomic force microscopy (AFM). Using force spectroscopy, single molecules (or pairs of interacting molecules), usually …

May 4, 2021 · Our versatile and extensible framework facilitates quantitative analysis of single molecule experiments at different experimental conditions.

Jan 7, 2026 · Abstract Single-molecule fluorescence experiments are a powerful tool for studying biomolecular interactions, including protein dynamics and oligomerization, protein–protein …

In addition to estimating the effective friction from experimental data, we also demonstrate how the models we use can quantify other sources of variation in single-molecule experiments.

Combined with fast CCD and modern microscopic equipment, single molecule FRET (smFRET) is the perfect tool to probe both spacial and temporal domains of molecular interactions.

Jul 2, 2025 · Explore methods for observing and manipulating single molecules, revealing the hidden dynamics and behaviors that traditional average measurements conceal.

Single molecule assays are methods that are used in combination of various biophysical, analytical or biochemical techniques to study single molecule.

Single-molecule experiments are techniques that allow scientists to observe and manipulate individual molecules in real time, providing insights into molecular behavior and dynamics.

A single-molecule experiment investigates the properties of a single individual molecule that can be isolated or distinguished for the purpose of an experiment or analysis.

Single molecule methods offer detailed insights into molecular mechanisms and interactions, complementing bulk assays with information that traditional methods often miss. These …