Dec 8, 2025 · This review provides a comprehensive overview of interferon signaling networks, molecular mechanisms, and pathophysiological roles across infectious, autoimmune, …

Aug 21, 2025 · Interferons (IFNs) are signaling proteins that play fundamental roles during health and disease. Although types I, II, and III IFNs are structurally and functionally different, all IFNs …

The interferon (IFN) pathway plays a critical role in the human immune response. Following viral infection, the human body triggers a complex regulatory system of innate and adaptive …

Dec 26, 2024 · Our findings uncover a primate-specific axis controlling interferon signaling and show how a transposon exonization event can be co-opted for immune regulation.

4 days ago · These results indicate that basal IFNλ2/3 signaling is essential for maintaining expression of core signaling components, such as STAT1, thereby priming intestinal epithelial …

Sep 4, 2025 · Interferon (IFN), first identified in 1957 as a biologically active molecule that inhibits viral replication, initiates antiviral and immunomodulatory responses through interaction with …

Apr 29, 2025 · Explore the intricate mechanisms of the interferon pathway, highlighting its components, signaling processes, and role in immune regulation.

Nov 12, 2020 · Here, we highlight similar and unique features of the IFNs, their cell surface complexes and discuss their role in inducing downstream IFN signaling responses. IFNs were …

This review provides a comprehensive overview of interferon signaling networks, molecular mechanisms, and pathophysiological roles across infectious, autoimmune, oncogenic, and …

Interferons (IFN) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. They are divided into three classes:Type I (predominantly IFN …