The first round of a four-day severe weather cylce slammed into Tennessee Wednesday night into Thursday morning killing at least four people.

A tornado warning has been issued for parts of Ohio, West Virginia, and western Pennsylvania. The National Weather Service says the warning includes parts of Eastern Belmont County in Ohio, parts of Marshall and Ohio counties in West Virginia, and parts of Greene and Washington counties in Pennsylvania.

The National Weather Service issued 10 tornado warnings in Southeast Missouri on April 2, with one EF-2 tornado confirmed. The storm caused structural damage but no injuries were reported.

Forecasters at the National Weather Service indicated all hazards are possible including tornadoes, damaging winds, and large hail Wednesday night.

When a warning is issued, take action. This means tornado conditions are imminent and have been spotted either by someone on the ground or by radar. Warning areas are typically smaller than those within a watch and are issued for a shorter time period, typically about 15 minutes.

For a replay of WOWK’s live coverage of the warning, click here. (WOWK) – Our StormTracker 13 Team is live on air and online as a Tornado Warning is in effect in part of our viewing

The National Weather Service in Charleston West Virginia has issued a Tornado Warning for Southern Nicholas County in southeastern West Virginia.

People in the warning areas are urged to seek shelter inside a sturdy building and stay away from windows until the threat is over.

"TAKE COVER NOW! Move to a basement or an interior room on the lowest floor of a sturdy building," the tornado warning said. "Avoid windows. If you are outdoors, in a mobile home, or in a vehicle, move to the closest substantial shelter and protect yourself from flying debris."

A powerful storm system will bring several life-threatening weather hazards to the Mid-South starting Wednesday night, including the threat of flash flooding and tornados, warns the National Weather Service.