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Restoration of full length filamin C is sufficient to prevent FLNC deficient cardiomyopathy in mice

Filamin C (FLNC) is an essential cytoskeletal protein required for cardiomyocyte structural integrity and mechanotransduction. Truncating FLNC variants cause haploinsufficiency associated with dilated ...
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Mitochondrial transplantation in humans: “magical” cure or cause for concern?

1 Comprehensive Heart Failure Center, University Clinic Würzburg, Germany. 2 Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Address correspondence ...
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Astrocytic glutamate transporter loss drives chemoreflex hyperactivity and cardiorespiratory dysfunction in a heart failure model

Esteban Diaz-Jara, Sinay C. Vicencio, Katherin V. Pereyra, Karla G. Schwarz, Fernando C. Ortiz, Camilo Toledo, Ignacio Bernal-Santander, Sandeep Kaur, Bisan El Dakkak, Rodrigo Del Rio ...
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Impairing Golgin-45 transcription factor activity unleashes malignant secretion in lung cancer

Chao Wu, Abhishek Kumar, Shike Wang, Weina Zhao, Yuanxin Xi, Jing Wang, Abhinav K. Jain, William K. Russell, Hou-fu Guo, Xiaochao Tan, Jonathan M. Kurie ...
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FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Blake D. Jardin, Feiyan Liu, Li Li, Cheryl L. Smith, Jonathan A. Epstein ...
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Mucus clearance as a primary innate defense mechanism for mammalian airways

Cystic Fibrosis/Pulmonary Research and Treatment Center, The University of North Carolina, Chapel Hill, North Carolina, USA Address correspondence to: Richard C. Boucher, Cystic Fibrosis/Pulmonary ...
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Monocyte-derived pro-angiogenic ocular macrophages identified by spatial transcriptomics are essential for choroidal neovascularization

1 Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, United States of America 2 Institute for Vision Research, The University of Iowa, Iowa City, United States ...
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Ciliary localization of GPR75 promotes fat accumulation in mice

Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA. Address correspondence to: Peter K. Jackson, ...
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Metformin Preserves Regional Brain Glucose Uptake, Structure, and Functional Connectivity in Adults with Insulin Resistance

3 Department of Radiology, Mayo Clinic, Rochester, United States of America 4 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, United States of America 5 Department of Psychiatry ...
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Targeting TET3 in macrophages provides a concept strategy for the treatment of endometriosis

Department of Obstetrics, Gynecology and Women’s Health, University of Missouri, Columbia, Missouri, USA. Address correspondence to: Jae-Wook Jeong, 1030 Hitt ...
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Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration

1 F.M. Kirby Center for Molecular Ophthalmology and 2 Department of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, ...
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DNAJC30 biallelic mutations extend mitochondrial complex I–deficient phenotypes to include recessive Leber’s hereditary optic neuropathy

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA. Address correspondence to: Janey L. Wiggs, Harvard Medical School, Massachusetts Eye ...