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Metformin Preserves Regional Brain Glucose Uptake, Structure, and Functional Connectivity in Adults with Insulin Resistance

3 Department of Radiology, Mayo Clinic, Rochester, United States of America 4 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, United States of America 5 Department of Psychiatry ...
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Impairing Golgin-45 transcription factor activity unleashes malignant secretion in lung cancer

Chao Wu, Abhishek Kumar, Shike Wang, Weina Zhao, Yuanxin Xi, Jing Wang, Abhinav K. Jain, William K. Russell, Hou-fu Guo, Xiaochao Tan, Jonathan M. Kurie ...
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Dopamine signaling via astrocytic D1 receptors regulates nucleus accumbens synaptic remodeling and cocaine seeking

1 Department of Neuroscience, University of Pittsburgh, Pittsburgh, United States of America 2 Department of Neuroscience, University of pittburgh, Pittsburgh, United States of America 3 Center for ...
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Astrocytic glutamate transporter loss drives chemoreflex hyperactivity and cardiorespiratory dysfunction in a heart failure model

Esteban Diaz-Jara, Sinay C. Vicencio, Katherin V. Pereyra, Karla G. Schwarz, Fernando C. Ortiz, Camilo Toledo, Ignacio Bernal-Santander, Sandeep Kaur, Bisan El Dakkak, Rodrigo Del Rio ...
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FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice

Blake D. Jardin, Feiyan Liu, Li Li, Cheryl L. Smith, Jonathan A. Epstein ...
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Restoration of full length filamin C is sufficient to prevent FLNC deficient cardiomyopathy in mice

Filamin C (FLNC) is an essential cytoskeletal protein required for cardiomyocyte structural integrity and mechanotransduction. Truncating FLNC variants cause haploinsufficiency associated with dilated ...
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Jet-injected combinational adjuvants potentiate naked mRNA vaccines for protection against respiratory viral infections in mice

1 Department of Advanced Nanomedical Engineering, Institute of Science Tokyo, Tokyo, Japan 2 Research Center for Infectious Diseases Medical Sciences, Tokyo Metropolitan Institute of Medical Science, ...
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PI3K signaling in breast cancer: therapeutic advances versus adaptive resistance

PI3K signaling and crosstalk with ERα and MAPK pathways.
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Resolving the links between efferocytosis and DNMT3A mutation–driven clonal hematopoiesis in atherosclerosis

Efferocytosis, or the clearance of apoptotic cells by macrophages, has been implicated in tissue resolution that promotes disease regression in atherosclerosis and other diseases of chronic ...
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Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Emily Feng, Alexa Mansour, Elizabeth Balint, Alyssa Mark, Sofia Tramonte, Jonathan K. Monteiro, Madison Read, Marie Joe Adaimy, Zhou Xing, Matthias Mack, Sergei V. Kotenko, Deanna M. Santer, Ali A.
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Insulin sensitivity and mitochondrial homeostasis connect lactation to maternal metabolic health

Lactation insufficiency in postpartum women has been associated with obesity and insulin resistance, among other risk factors. Challenges related to translating findings from animal models of ...
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Cells heal themselves: gene-edited hematopoietic stem cells restore frataxin deficiency in multiple organs

Friedreich’s ataxia (FRDA) is a triplet repeat expansion disorder with multisystem, progressive symptoms caused by reduced frataxin protein levels and compromised mitochondrial function. Restoration ...