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Transformative improvement with staggered gains in rheumatoid arthritis remission and sustained remission, but higher relapse rates: a population-based cohort study …

Objectives To report population-level data describing long-term trends in remission, sustained remission and relapse among ...
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Frequency and predictors of disease progression in contemporary ACPA-negative undifferentiated arthritis in a treated-to-target early arthritis clinic

Objectives Since the introduction of the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (EULAR) criteria, undifferentiated arthritis (UA) has become ...
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Effectiveness of second-line biologics in juvenile idiopathic arthritis: the IIBIOJIA Study

Objectives To describe the prescription patterns of second-line biological disease-modifying antirheumatic drugs (bDMARDs) in non-systemic juvenile idiopathic arthritis (JIA) and to assess the ...
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First trimester exposure to hydroxychloroquine during pregnancy and major congenital malformations: a systematic review and meta-analysis

Objective To assess the association between hydroxychloroquine (HCQ) use during the first trimester of pregnancy and the risk of major congenital malformations (MCMs). Methods In this systematic ...
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Rheumatoid factor and anticitrullinated protein antibody status jointly influence the association between disease activity and cardiovascular risk in rheumatoid arthritis

Objectives Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are linked to disease activity, severity and cardiovascular risk in rheumatoid arthritis (RA). Since RA-related ...
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Triple jump for the optimal management of psoriatic arthritis: diet, sleep and exercise – a review

Psoriatic arthritis (PsA) is a complex, multiform and chronic inflammatory disease characterised by the association of arthritis and psoriasis combined with other related conditions and comorbidities.
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Oral bisphosphonates and risk of incident osteoarthritis in individuals with osteoporosis: a target trial emulation

Objectives Owing to the underrepresentation of early-stage disease in randomised trials and inconsistent clinical evidence, using oral bisphosphonates to prevent incident osteoarthritis in adults with ...
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Dance as a double-edged sword: physiological adaptations, injury risks and therapeutic potential

Dance is a complex physical activity with high biomechanical and artistic demands that cause repetitive stress on the musculoskeletal, neuromuscular, metabolic and cardiorespiratory systems. Dance ...
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Efficacy of etanercept in combination with methotrexate in moderate-to-severe rheumatoid arthritis is not dependent on methotrexate dosage

Objective To evaluate the impact of methotrexate (MTX) dosage on clinical, functional and quality of life outcomes in patients with rheumatoid arthritis (RA) from two previous etanercept (ETN) trials ...
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Prevalence and clinical relevance of anti-drug antibodies in psoriatic arthritis: a systematic review

Objectives To determine the prevalence of anti-drug antibodies (ADAs) in patients with psoriatic arthritis (PsA) treated with biological disease-modifying antirheumatic drugs (bDMARDs) and to evaluate ...
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Are investigator-initiated clinical trials becoming an ‘endangered species’?

Investigator-initiated clinical trials (IITs) are at the core of innovative thinking in health research generating data in real-world settings that influence global policy. Although diminished funding ...