Objectives Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin condition with no approved targeted treatments. Afimetoran – a first-in-class, once daily oral, selective, equipotent, ...

Objectives Systemic lupus erythematosus (SLE) is a chronic, immune-mediated disease that can affect multiple organ systems, causing debilitating symptoms, organ damage and impaired quality of life.

Objectives This study aimed to derive and validate a cut-off for severe disease activity (SDA) using the SLE Disease Activity Score (SLE-DAS) and compare its accuracy and impact on health-related ...

Objective SLE is prevalent among women of reproductive age, increasing the risk of adverse pregnancy outcomes (APOs). However, the correlation between the onset time of SLE and APOs remains unclear.

1 Rheumatology Unit, Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy 2 Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, ...

Objective To develop a Register-Based Organ Damage Index (RBODI) in SLE, and evaluate its accuracy in estimating Systemic Lupus International Collaborating Clinics/American College of Rheumatology ...

Objectives Flares may still occur after remission, affecting organ damage accrual and survival expectancy. Therefore, identifying predictors of these flares is clinically relevant, particularly in ...

Objective Limited examinations from prior studies support the absence of retinal toxicity in infants exposed to maternal ...

Objectives Lupus Low Disease Activity State (LLDAS) and Definition of Remission in SLE (DORIS) are associated with improved ...

Objective Outcome measures used in SLE randomised controlled trials (RCTs) have impeded trial success and drug approval. In ...

Objectives To investigate the real-world incidence of serious infections (SI), herpes zoster (HZ) and hepatitis B virus (HBV) ...

Objective To characterise the safety and efficacy of anifrolumab in active lupus nephritis (LN) through year 2 of the phase II randomised, double-blind Treatment of Uncontrolled Lupus via the ...