Employees across the massive U.S. Health and Human Services Department received notices Tuesday that their jobs were being eliminated, part of a sweeping overhaul designed to vastly shrink the agencies responsible for protecting and promoting Americans’ health.

The CDC laid off around 2,400 employees on Tuesday across a wide range of divisions from global HIV prevention to smoking research. One was a research scientist who is expecting a baby in a few days.

The US Department of Health and Human Services announced the elimination of up to 10,000 positions as part of a major restructuring. Key agencies like the FDA, CDC, and NIH will face significant layoffs,