The Crew-10 astronauts will replace four crew members who have been aboard the ISS for an extended stay—NASA’s Nick Hague, Suni Williams, and Butch Wilmore, along with Roscosm

Reaching orbit from NASA’s Kennedy Space Center, the newest crew includes NASA’s Anne McClain and Nichole Ayers, both military pilots; and Japan’s Takuya Onishi and Russia’s Kirill Peskov, both former airline pilots. They will spend the next six months at the space station, considered the normal stint, after springing Wilmore and Williams free.