A cross-country storm dumping snow across the Midwest has led to hundreds of canceled flights and snowy roads, including a 45-car pileup on one Indiana highway, amid the post-Thanksgiving travel rush.

A major winter storm blasted parts of the Midwest and the Central U.S. this weekend with heavy snowfall, causing travel nightmares for millions of people as they return home from Thanksgiving plans.

The Thanksgiving weekend storm system has brought over a foot of snow and strong winds to parts of the Midwest, and thunderstorms across the South.

For those traveling for the Thanksgiving holiday, a series of winter weather alerts could have big impacts on road trip plans.

Cleveland anticipates mixed weather, including warm temperatures, wind gusts up to 50 mph, and lake-enhanced snow with potential coastal storm snowfall midweek.

While we finish our Thanksgiving food and head back home, loads of people in the upper-Midwest are in store for a MAJOR cool down going into next week. The Climate Prediction Center has great confidence of seeing some well below average temperatures going into early December.