Ultra-deep long-read sequencing has delivered the first telomere-to-telomere sequence of the non-Mendelian ribosomal DNA ...

In the 1930s, Hermann Muller was the first researcher to note that the ends of chromosomes had unique properties. Muller ...

New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought. Half a century ago, scientists Jim Watson and Alexey Olovnikov ...

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied. A quirk of linear DNA replication dictated that telomeres ...

The initiation of chromosome replication is exquisitely regulated in both time and location. It has been estimated that there are 200-400 autosomal replication sequence elements (ARSs) in the yeast ...

It's tricky to make an exact copy of yourself. Or at least it is for cells undergoing mitosis, where cells replicate everything inside of them, including their neatly packaged DNA, then split in half.

Human DNA, which is approximately two meters in length, is organized into a compact, thread-like structure known as the chromatin, so it could fit into the nucleus, a tiny sphere that’s only about six ...

A team of researchers has uncovered a previously unknown mechanism that can disrupt DNA replication at the ends of chromosomes, shedding new light on one of the most fundamental challenges faced by ...