Improvements in medical therapy, carotid-artery stenting, and carotid endarterectomy call into question the preferred ...

The management of carotid-artery stenosis that has not caused recent symptoms — asymptomatic carotid stenosis — has been controversial. Clinical trials that began more than 30 years ago showed a small ...

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 20).

A 26-year-old woman was referred to the pulmonary hypertension clinic with a 6-month history of exertional dyspnea and hoarseness. Vocal-fold paralysis was seen on laryngoscopy (shown in a video).

This feature about a man hospitalized for uncomplicated diverticulitis who is found to have high blood pressure offers a case vignette accompanied by two essays, one supporting watchful waiting and ...

Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The FDA outlines a path to market entry for products where a randomized trial is no ...

To the Editor: The landmark findings of the CheckMate 816 trial, conducted by Forde et al. (Aug. 21/28 issue), 1 showed a significant survival benefit with neoadjuvant nivolumab plus chemotherapy in ...

To the Editor: The results of the C-POST trial, reported by Rischin and colleagues (August 21/28 issue), 1 highlight improvements in disease-free survival with adjuvant cemiplimab. As the authors ...

We conducted an international, open-label, randomized, blinded-outcome-assessment trial involving 1284 patients who had undergone successful catheter ablation for atrial fibrillation at least 1 year ...

Both tobevibart (a monoclonal antibody) and elebsiran (a small interfering RNA) target hepatitis B virus surface antigen (HBsAg). Their efficacy and safety in the treatment of chronic hepatitis D ...

Approximately 5 million persons in the United States have psoriasis. 1 Most have mild disease covering less than 3% of body-surface area, but approximately one fifth have more extensive involvement ...

More than 470,000 patients with kidney failure receive hemodialysis in the United States alone, with worldwide estimates approaching 3 million patients. Mortality from kidney failure remains ...