During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

The US administration has extended its line of attack on academia from US federal research to private universities. The abuse of international students is both ethically wrong and ultimately ...

Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC ‐associated changes of fecal microbiota and their potential for cancer screening remain to be ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

imageimageThis study developed a systematic workflow leveraging transcriptomics and metabolomics to identify input signals for 41 transcription factors in E. coli. A systematic workflow was developed ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

FANCM employs a sophisticated dual recognition mechanism in genome maintenance, using distinct DNA-binding domains to identify and move around on branched DNA structures. This study reveals how FANCM ...

imageimageThe respective contribution of tumour suppressor p53-activated cellular response pathways to prevention of tumour development remains debated. This resource introduces three novel mouse ...

Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can ...

imageimagemiR153 regulates inhibitory synapses by controlling translation of the major inhibitory synaptic scaffold, gephyrin. During plasticity, miR153 is transcriptionally repressed enabling ...

imageimageMultiple inter- and intra-molecular interfaces stabilise the overall three-dimensional architecture of the Mis18 complex and ensure centromere localisation and function of the CENP-A loading ...