Current bone marrow transplant treatment of cancer patients does not include agents to amplify the number of repopulating stem cells. A step closer to developing an appropriate drug has been made by ...

Medulloblastoma is the most common malignant brain tumor in children, and the sonic hedgehog (SHH) subtype accounts for ...

St. Jude Children's Research Hospital scientists have uncovered a regulatory mechanism for signaling of Sonic Hedgehog (SHH), a pathway essential for embryonic development. The findings, published in ...

Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is induced by sterols, ...

Scientists at the IRCM and the University of Montreal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumour found in children. The team, led by Frederic ...