Researchers at the University of Osaka have developed a simple culture method that converts B cells isolated from human blood ...

In a recent online publication in Science China Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of ...

Somatic hypermutation, gene conversion and class-switch recombination are genetic rearrangements that generate the molecular diversity of immunoglobulin genes underlying the human immune system. In ...

Researchers at the University of Osaka have developed a streamlined laboratory method that uses just three sequentially ...

Three immune signals delivered in sequence produce human B cells with germinal center featuresResearchers at the University ...

A research team led by Associate Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, and Professor Hironobu Minami of the Division of ...

Nanopore sequencing offers comparable accuracy to short-read NGS for IGH clonotyping in CLL, with advantages in cost and laboratory footprint. The study confirms reliable somatic hypermutation status ...

Scientists from the Republic of Korea have analyzed B-cell receptor repertoires induced by an mRNA-based coronavirus disease 2019 (COVID-19) vaccine and found that somatic hypermutations in B-cell ...

About 2 meters (6.6 feet) of genetic material must fit into the nucleus of each of most of our trillions of cells, coiling and winding to form what looks like a tangled mess. But when genes are used, ...