Mast cells are central effectors in asthma, acting as both initiators and amplifiers of airway inflammation. Residing in peribronchial tissues and the epithelium, they respond to immunoglobulin E (IgE ...
Immune cell trapping during allergic responses Mast cells, residing in tissues and critical for initiating inflammation, are filled with granules containing pro-inflammatory substances. These granules ...
Scientists at Duke-NUS Medical School have identified how the first domino falls after a person encounters an allergen, such as peanuts, shellfish, pollen or dust mites. Their discovery, published in ...
Groundbreaking research from Duke-NUS offers new hope to millions with asthma and severe food allergies, signalling a new strategy for the prevention of life-threatening reactions Scientists at ...
Mast cells accumulate in breast cancer, but there is only limited knowledge of how they impact on breast cancer growth. Here we show that tryptase, a major compound stored in mast cell secretory ...
– Data provide insights on the signaling pathways involved with AK006 mast cell inhibition –– AK006 has a distinct mechanism of action that leads to broad inhibitory effects on mast cells – The ...
This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...
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