For many years, researchers believed that the DNA inside a newly fertilized egg began as a structural ‘blank slate’ – a loose ...

Scientists discover hidden DNA scaffolding that forms before genes activate, revealing life’s blueprint is built before it begins.

Left: staining for H3K27me3, which marks inactive DNA, on a nucleus of a wildtype embryo consisting of two cells Right: staining for H3K27me3, which marks inactive DNA, on a nucleus of an embryo ...

Researchers from the Kind Group have gained new insights into the mechanism behind the spatial organization of DNA within the cells of early embryos. When an embryo is first formed after fertilization ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

In a discovery that could redefine how we understand cellular resilience and adaptability, scientists have unlocked the secret interactions between a primordial inorganic polymer of phosphate known as ...

DNA has to be carefully packaged and organized in cells so it will both physically fit into the nucleus, and also remain accessible to the cellular machinery that transcribes active genes. Together, ...

An article by UAB professor Joan-Ramon Daban analyzes in depth the physical problems associated with DNA packaging that have often been neglected in structural models of chromosomes. The study ...

The protein complex that holds strands of DNA in compact spools partially disassembles itself to help genes reveal themselves to specialized proteins and enzymes for activation, according to Rice ...