This is a preview. Log in through your library . Abstract We have monitored histone acetylation during conjugation of the ciliated protozoan Tetrahymena thermophila using antibodies against the ...

The biology of histone proteins encompasses their synthesis in the cytosol, nuclear import and incorporation into nucleosomes, as well as subsequent eviction from chromatin, redeposition, storage or ...

In chromosomes, DNA is wrapped around proteins called histones. These histones are crucial for efficient packaging of DNA, as well as the replication and segregation of chromosomes themselves. Due to ...

A new study shows how histones undergo correct chemical modifications during synthesis to guide new therapies.

Phase I study of oral suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, in patients (pts) with advanced leukemias or myelodysplastic syndromes (MDS) ...