A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human ...

While the large proportion of our genome that does not instruct our cells to form proteins has been harder to study than protein-coding genes, it has been shown to have vital physiological functions.

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins ...

Eukaryotes are organisms whose cells contain a nucleus. From protozoa to human beings, all have the same basic biological ...

Using STING-seq, short for systematic targeting and inhibition of noncoding GWAS loci with single cell sequencing, Sanjana and his team identified promising sequence variants linked to various ...

We present here a structural and mechanistic description of how a protein changes its fold and function, mutation by mutation. Our approach was to create 2 proteins that (i) are stably folded into 2 ...

The expression pattern of a single gene or multiple genes can be investigated using a technique RNA microarray. In this technique, RNA molecules are ‘spotted’ onto a solid surface. These act as probes ...

When the logarithmic function is approximated by sequences of algebraic functions, similar questions can be posed as in the case of other similar problems. So, for example, it is interesting to ...

Have you ever found yourself endlessly dragging that little Excel fill handle, trying to populate rows or columns with numbers, dates, or formulas? It’s tedious, time-consuming, and let’s be ...