In a recent study published in Nature Biotechnology, researchers developed a whole-genome sequencing (WGS) method that read four canonical deoxyribonucleic acid (DNA) bases, viz., adenine (A), ...

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations. Early life forms on Earth are likely to have mutated and evolved at much higher ...

The DNA base cytosine has a lot of different outfits in its closet. Most famously, the base can slip on a methyl group at its fifth carbon, a change that lends cytosine the ability to silence genes.