Mount Sinai researchers took detailed pictures of the serotonin receptor and clinically-validated drug target 5-HT1A using cryo-electron microscopy to show how the psychedelics LSD and 5-MeO-DMT and a ...

A viral park warning revived myths about psychedelic toads, but scientists say licking them brings danger, conservation risks ...

The psychedelic 5-MeO-DMT seemed to induce similar patterns of brain activity in a lama - a revered spiritual teacher in Tibetan Buddhism - as meditation, advancing our understanding of the drug's neu ...

Understanding exactly how psychedelics promote new connections in the brain is critical to developing targeted, non-hallucinogenic therapeutics that can treat neurodegenerative and neuropsychiatric ...

Most psychedelics flood the mind with a barrage of images, thoughts, and sensations. But a new study from University College London suggests that 5-MeO-DMT does the opposite, stripping brain activity ...

Psychedelics such as psilocybin are showing promise as potential therapeutics for psychiatric disorders such as depression, with rapid and long-lasting effects. Investigations into their mechanism of ...

Psychedelics—frequently recognized as substances such as LSD, psilocybin, and DMT—not only alter perception, mood, and cognition, but they often cause hallucinations. That said, they have also been ...

Depression can be treated by many drugs, but for many patients the available therapies just aren’t good enough. Treatment-resistant depression remains an unmet medical need and psychedelic compounds ...

Hallucinogenic compounds that activate multiple receptors, found in Colorado River toads, show “promising transdiagnostic therapeutic with rapid and lasting effects” for conditions such as depression ...

Researchers at the Icahn School of Medicine at Mount Sinai have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to ...