Employees across the U.S. Department of Health and Human Services have begun receiving notices of dismissal in a major overhaul expected to ultimately lay off up to 10,000 people.

Layoffs of 10,000 Health and Human Services employees begin. Agencies devoted to seniors, minorities and HIV prevention closed

The National Institute of Occupational Safety and Health employs 403 people in Cincinnati. They may lose their jobs.

The Department of Health and Human Services on Thursday announced plans to cut 10,000 employees amid an executive order from President Donald Trump to downsize federal agencies.

Switzer Memorial Building in Washington on Tuesday.Credit...Roberto Schmidt/Agence France-Presse — Health job cuts: The Trump administration laid off thousands of federal health workers, dismissing senior leaders and top scientists in a purge that outside experts and former officials said would cause an immeasurable loss of expertise.

E mployees of the U.S. Department of Health and Human Services (HHS) knew that mass layoffs would be coming on April 1. But many did not expect the cuts to be so deep—or the implications of the layoffs to be so potentially detrimental to the health and wellbeing of American families.

The move comes after Secretary Robert F. Kennedy Jr.’s announcement of a sweeping reduction of the Department of Health and Human Services.

The Trump administration on Tuesday began mass layoffs of 10,000 staff at US health agencies, with security personnel denying entry to some employees just hours after they received termination notices