After another inept defensive performance and a hallow offensive output, the Arizona Cardinals sit at 3-7 and now host the Jacksonville Jaguars on Sunday. The Jaguars only open as small favorites, so things are not completely off the rails yet.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) throws the ball while Arizona Cardinals defensive lineman Walter Nolen III (97) defends in the first half at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images / Matt Kartozian-Imagn Images

When Jonathan Gannon took over as coach of the Arizona Cardinals he laid out key expectations. But the team is again mired in a disappointing season.

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

Find out why our Jaguars vs. Cardinals predictions see Jacksonville escaping with a shootout win over Arizona in Week 12.

With the activation of linebacker BJ Ojulari from PUP Saturday and the addition of linebacker Mack Wilson Sr. to IR, the Cardinals now have 13 players placed on IR since the cut to 53, three on IR prior to the cut to 53 and one, cornerback Sean Murphy-Bunting, on reserve/non-football injury, also done prior to the reduction to 53.

Walter Nolen III, a defensive tackle out of Ole Miss, was scouted by the 49ers, who instead took Mykel Williams with the No. 11 pick in the first round. Nolen went to the Cardinals at No. 16 and didn’t make his debut until two weeks ago because of a late-July calf injury.

Arizona Cardinals running back Trey Benson, who replaced an injured James Conner, is sidelined with a brutal knee injury sustained in Week 5. Despite

The Cardinals' Week 11 game against the 49ers will basically only get coverage in the two teams' home viewing markets.